Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: Effect on Spreading Depolarizations

Abstract

This report describes Year 4 progress in clinical studies to determine the impact of temperature management on spreading depolarizations (SD) and outcomes in severe traumatic brain injury (TBI), following SOW revision in Year 3. In this year, ethical approvals were obtained to address research questions using existing clinical databases from the W81XWH-08-2-0016 (Objective 1) and TRACK-TBI (NIH U01; Objective 2)studies. Statistical approaches and custom programs were developed for Obj.1. In analysis of hourly physiologic data (n=2229),results demonstrated significant effects of increased temperature (>36 C), lower blood pressure, and lower heart rate to increase risk of SDs as recorded from the brains of TBI patients. Each variable showed an independent effect in multivariate logistic regression. The model predicted the occurrence of SDs with 80% accuracy, 40% sensitivity, and 80% specificity on a nave test data set. Results suggest a simple physiologic model of SD prediction to generalize principles of SD for patient care. Obj. 2 will be pursued in the next period.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1119028

Entities

People

  • Jed A Hartings

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Contracts
  • Craniocerebral Trauma
  • Data Analysis
  • Data Sets
  • Databases
  • Department Of Defense
  • Depolarization
  • Heart Rate
  • Hemorrhage
  • Hypothermia
  • Information Science
  • Medical Personnel
  • Statistical Analysis
  • Temperature Control

Fields of Study

  • Medicine

Readers

  • Computational Modeling and Simulation
  • Trauma Surgery or Emergency Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.