Sorption of Carfentanil and Remifentanil Salts on Porous Materials
Abstract
Interest in characterization of opioids has increased over the last few years as the U.S. tries to combat the opioid crisis. However, a lot of the work has focused around opioids inside the human body. This study focused on opioid interactions with surfaces outside of the body to potentially prevent opioids from ever entering the body. Sorption studies were performed for carfentanil citrate and remifentanil oxalate salts on SiO2 and metal organic framework (MOF) surfaces in solution. The binding of these opioids was significantly affected by the type of solvent and pore aperture size of the material. For carfentanil in methanol, all surfaces except NU-1000 showed little to no binding of the opioid with the surface; however, when water was added to the solution, opioid binding increased dramatically for the MOFs with large pore sizes as well as for UiO-66-NH2, which has possible reactive amine groups and missing linker defects. Remifentanil had minimal binding to the surfaces except at 100 water for large pore size MOFs. The remifentanil salt was readily hydrolyzed in solution, but when the MOFs were added, the remifentanil stabilized, likely due to the lower pH of the solution.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2021
- Accession Number
- AD1120631
Entities
People
- Amanda Schenning
- Gregory W. Peterson
- Ivan Iordanov
- Michelle Sheahy
- Monica L McEntee
Organizations
- United States Army Combat Capabilities Development Command