The Imprint of Psychogenic Non-Epileptic Seizures on the Brain: A New Model and Imaging Biomarker

Abstract

The goal of the project is to obtain evidence to support a new mechanism that assumes that PNES are caused by a predisposition for enhanced synchronization/overshooting recruitment of brain regions involved in emotion control/processing of traumatic/stressful experiences. By assuming such a predisposition, the project implicitly assumes that PNES have a specific biological underpinning. Participant recruitment was difficult from the beginning and was addressed by finding and adding additional referral sites (UCSF, Stanford). Due to the COVID-19 outbreak all non-essential research activities requiring interaction with human subjects was suspended at CIND from March until end of August 2020. At the time 11 patients and 2 controls had completed all research procedures and 3 people were scheduled to be studied. To the degree possible the time since March 2020 has been used to process and analyze all imaging data, adapt the IRB protocol to allow for remote tests/exams for interviews, questionnaires etc.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1120872

Entities

People

  • Susanne G Mueller

Organizations

  • Northern California Institute for Research and Education

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DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Brain
  • California
  • Comorbidity
  • Covid-19
  • Data Processing
  • Data Sets
  • Databases
  • Department Of Defense
  • Education
  • Electronic Mail
  • Epilepsy
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  • Health
  • Maryland
  • Medical Personnel
  • Mental Health
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  • Questionnaires
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Readers

  • Canadian European Scientific Immigration and Epilepsy Clearance Studies
  • Clinical Trial Research.
  • Oncology