Neuroimaging Biomarker for Seizures
Abstract
The multi-site study will examine patients with epilepsy (ES) following head injury [i.e.,posttraumatic epilepsy (PTE)] and posttraumatic Psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures. The research aims to investigate: 1. Differences in cerebral underpinnings of emotion and stress processing in PNES and PTE; 2. Neuroimaging biomarker of PTE and PNES that predicts treatment outcome in order to inform effective non-pharmacologic treatments for seizures; and 3. Evidence for a positive treatment response to the intervention (Cognitive Behavioral Therapyfor Seizures (CBT-Sz), a manualized behavioral therapy program) that result in neuroplasticity. This study aims to enroll 264 participants (Veterans and civilians) divided over the sites: 88 with PNES, 88 with PTE, and 88 with TBI without PNES or PTE. Over the past year, we established multi-site infrastructure, obtained regulatory approval, started enrollment and preliminary data analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1120887
Entities
People
- William C. Jr Lafrance
Organizations
- Ocean State Policy Research Institute