A Novel Visually Graded CT Biomarker of Preinjury Brain Structure to Improve Prediction of Cognitive Decline After Mild Traumatic Brain Injury

Abstract

Mild traumatic brain injury (mTBI) is a signature injury of modern warfare and affects an estimated 42 million people worldwide each year. MTBI may lead to chronic cognitive problems (in memory and thinking ability) in up to half of patients. Even more concerning is that mTBI may lead to progressive cognitive decline and eventual Alzheimers dementia (AD) and AD related disorders (ADRD),increasing risk by up to 3-fold. There are currently no practical tools to accurately predict who will suffer from chronic or progressive cognitive consequences of mTBI and who will recover uneventfully. Our project will directly address the overarching challenge of the need for biomarkers and tools to prognose cognitive decline and subsequent progression to AD/ADRD after mTBI.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1120915

Entities

People

  • Raquel C Gardner

Organizations

  • Northern California Institute for Research and Education

Tags

DTIC Thesaurus Topics

  • Algorithms
  • Alzheimer Disease
  • Biological Markers
  • Biomedical Research
  • Brain Injuries
  • California
  • Clinical Trials
  • Cognitive Impairment
  • Data Analysis
  • Data Management
  • Dementia
  • Department Of Defense
  • Diseases And Disorders
  • Education
  • Information Science
  • Machine Learning
  • Medical Personnel
  • Neural Networks
  • Neurodegenerative Diseases
  • Public Health
  • Reliability
  • Training

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.