Clarifying the Role Played by Microglia and Astrocyte Activation in Veterans with Gulf War Illness Using Positron Emission Tomography (PET)
Abstract
The study objective is to assess whether veterans with GWI will show evidence of a chronic inflammatory process as measured by increased levels of astrocyte and microglial activation. We will determine the regionally specific pattern of astrocyte activation in20 GW veterans. We will determine if there is regional independence of the astrocyte activation from microglial activation and we will assess the utility of using FDG PET as a marker for activated astrocytes. We have been focusing on obtain appropriate approvals while working with institutions where only limited in person research has been allowed. This study will take place at Mass General Brigham Hospital and Boston University School of Medicine. We have set up the subcontract between these institutes. We have gotten feedback and responded to questions by the MGH IRB. We have the BUMC IRB ready for submission and the BBRAIN study that we expect to recruit from has approval for in person visits allowing us to begin inquiries of interest in this study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1121019
Entities
People
- Ronald Killiany
Organizations
- Boston University Medical Campus