Identification of Mechanisms Underlying the Effects of Plasma Inclusive Resuscitation in Major Thermal Injury on Hemostasis and Vascular Homeostasis
Abstract
Recently, investigation is re-emerging on optimizing burn shock resuscitation. Areas of interest include a variety of strategies for reducing volume requirements (as would be needed in an austere environmentor where prolonged field care is required). Colloid is again being trialed in attempts to improve the response to vascular leakage, intravascular volume expansion and reduction of volume. Off-the-shelf colloid options include human serum albumin and fresh frozen plasma (FFP). Many prescribers of FFP report great response in regards to intravascular volume expansion with minimal side effects, though some reports exist of transfusion associated complications. Unfortunately, little is known about the impacts of these transfusion products on thermally-injured patients. Hence this proposal outlines a study that will elucidate the impact of a plasma-inclusive resuscitation (PIR) which will advance strategies for prolonged field care (i.e. freeze-dried plasma). We hypothesize that a PIR alters coagulation homeostasis in a positive manner while combating the effects vascular endothelial dysfunction and modulating the inflammatory host response. This prospective, systematic, and comprehensive characterization of FFP and its impacts on hemostatic and inflammatory potential of burn patients will be broadly applicable because it will serve to advance the body of knowledge available on blood products. By addressing these and previously cited gaps in research, the refinement of both plasma products and transfusion strategies for a large population of patients may be accelerated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1121026
Entities
People
- Jeffrey W. Shupp
- Lauren Moffatt
- Melissa Mclawhorn
Organizations
- MedStar Health Research Institute