Characterization of the Biomechanical Heterogeneity of Neurofibromas and Malignant Peripheral Nerve Sheath Tumors
Abstract
To investigate the role that biomechanical factor play in the development and progression of neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis type 1, this research project will mechanically characterize those tissues from two mouse models and develop an in vitro model to isolate the contributions of the various cells and matrices. In this period we learned that mouse breeding for the neurofibroma model must be performed at RPI, not at MUSC as originally planned. This has delayed the submission of the IACUC protocol. However, we have worked on aspects of the project that are possible to do using cell lines. This has allowed us to develop and troubleshoot experimental protocols and make specific hypotheses based on disease state to test with the in vivo model and primary cells. The graduate student working on the project presented a poster at the 2020 NF Virtual Conference.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1121684
Entities
People
- Kristen L. Mills
Organizations
- Rensselaer Polytechnic Institute