T cells and Rejection in Vascularized Composite Allotransplants

Abstract

Immune rejection is a major barrier to wider implementation of vascular composite allografts (VCAs) that hold great promise for restoring function in American service members, who have suffered devastating traumatic injuries. Despite systemic immunosuppression, T cell mediated rejection (TCMR) occurs much more frequently in VCA than in solid organ transplants, likely due to the significant number of T donor T cells that survive in the allografts. This study will used banked tissues from VCA patients to comprehensively analyze the contributions of donor versus recipient T cells in VCA rejection. Another question that will be addressed is whether sentinel flaps, transplanted concomitantly with the allograft from the same donor to a distant anatomical site, or circulating levels of clonally expanded T cells, are useful as reliable markers for VCA rejection. IRB approval for this project has been obtained and HRPO approval is pending.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1121750

Entities

People

  • Rachel Clark

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Blood Cells
  • Cells
  • Composite Materials
  • Department Of Defense
  • Electronic Mail
  • Health Services
  • Hospitals
  • Information Operations
  • Internet
  • Law
  • Lymphocytes
  • Maryland
  • Medical Personnel
  • Monitoring
  • Professional Development
  • Rejection
  • Rna Sequence Analysis
  • Technology Transfer
  • Throughput
  • Tissue Donors
  • Transplants
  • Upper Extremity

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neuroscience
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology