Examination of Neuroimaging, Cognitive Functioning, and Plasma Biomarkers in a Longitudinal Cohort: Fort Devens

Abstract

This study aims to conduct follow-up longitudinal cognitive evaluations on a sub-sample of 100 Time 3 Ft. Devens Cohort veterans, most of whom were last evaluated in-person for cognitive functioning and with neuroimaging in the mid-1990s, to compare objective measurement of reported decline; and to determine cross-sectional blood and neuroimaging biomarkers (blood and structural volumetrics will also include longitudinal analyses) at 25 years post deployment to the Gulf region, that may be consistent with cognitive outcomes and presumed pathobiological mechanisms (oxidative stress, ROS) of GWI. These data will evaluate the utility of previously unavailable blood and neuroimaging markers of oxidative stress, to devise a new diagnostic test for GWI in subgroups of GW veterans (TBI and OP exposed), and to provide a potential objective biomarker of treatment efficacy in clinical trials.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1122436

Entities

People

  • Maxine H Krengel

Organizations

  • Boston VA Research Institute

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Central Nervous System
  • Clinical Trials
  • Data Analysis
  • Delivery Of Health Care
  • Department Of Defense
  • Diseases And Disorders
  • Environmental Exposure
  • Experimental Design
  • Health
  • Health Care
  • Health Services
  • Institutional Review Board
  • Nervous System
  • Neuroimaging
  • Persian Gulf Syndrome
  • Public Health
  • Stress (Physiology)
  • Test Methods
  • Therapy

Fields of Study

  • Medicine
  • Psychology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.