Anti complement Therapy to Improve Mortality and Morbidity for Traumatic Hemorrhage during Prolonged Field Care and Prolonged Damage Control Resuscitation

Abstract

Bleeding (hemorrhage) after trauma remains a leading cause of death. Traumatic hemorrhage (TH) causes early innate immune response and clotting disorders. An inappropriate innate immune response after TH leads to an abnormal release of inflammatory mediators that contribute to early inflammation-mediated multi-organ failure (MOF) and death. Complement cascade (ComC) as a first line defense and a master alarm system of the innate immunity, represents a key mechanism to prime overzealous cytokine storm and thromboinflammation that contribute to multi-system inflammatory syndrome (MSIS)-mediated MOF after TH. The purpose of this study is to develop and validate anti-ComC therapies aimed at mitigating the MSIS-induced MOF and increasing survival, thereby improving outcomes during prolonged field care and/or prehospital scenario for TH patients.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1122441

Entities

People

  • Yansong Li

Organizations

  • Geneva Foundation

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Arteries
  • Biomedical Research
  • Blast Injuries
  • Contracts
  • Covid-19
  • Cytokines
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Employment
  • Health Services
  • Hemorrhage
  • Hemorrhagic Shock
  • Inflammation
  • Inhibition
  • Inhibitors
  • Lung Diseases
  • Medical Personnel
  • Resuscitation
  • Shock Tubes
  • Therapy
  • Veins
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Trauma or Military Medicine