Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

Abstract

We are interested in determining whether ambient air pollutants impact the development of Parkinson's disease by increasing alpha-synuclein (alpha-syn) pathology via inflammation. After completing Specific Aim 2, wherein we found no differences between experimental groups in spread of alpha-syn, we discovered our collected nPM did not produce the expected neuroinflammatory changes. We repeated Specific Aim 2 mouse experiments with a new batch of nPM before SARS-CoV-2 quarantine. After restrictions were relaxed, we analyzed spread of alpha-syn using a novel AI, but found no difference between brains of nPM- and forced air-exposed mice. We are in communication with our collaborators at USC in order to plan and execute novel experiments to explore the effects of LPS-induced olfactory inflammation on spread of alpha-syn by histological (VARI) and biochemical (USC) analyses under continued quarantine and travel restrictions.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2020
Accession Number
AD1122863

Entities

People

  • Patrik Brundin

Organizations

  • Van Andel Institute

Tags

DTIC Thesaurus Topics

  • Air Pollutants
  • Airborne
  • Algorithms
  • Alzheimer Disease
  • Artificial Intelligence
  • Biomedical Research
  • Confocal Microscopy
  • Covid-19
  • Cytokines
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Inflammation
  • Medical Personnel
  • Nervous System
  • Parkinson'S Disease
  • Pathology
  • Quarantine
  • Sars
  • Students
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Immunology and Pathology
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.