Multi-Omics and Mitochondrial Dysfunction in Acute Lung Injury

Abstract

Traumatic injury is a leading cause of respiratory failure, where 2-4 of persons with trauma develop acute lung injury/ acute respiratory distress syndrome (ALI/ARDS). Septic shock with acute organ dysfunction is a common complication of severe trauma, with 40 of estimated mortality rates. A key feature in trauma-associated ALI/ARDS and sepsis is the impairment of pulmonary vascular integrity. During sepsis, ALI/ARDS results from activation of innate immune cells and endothelial cells by endotoxins leading to systemic inflammation and oxidative stress, which results in endothelial cell death and loss of integrity of the pulmonary vascular endothelium. However, the mechanisms leading to ALI/ARDS remains elusive.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1122935

Entities

People

  • Andriy I. Batchinsky
  • Guogang Xu
  • Hongping Ye
  • John J Kim
  • Kumar Sharma
  • Madesh Muniswamy
  • Pragya Singh
  • Viktor Drel
  • Xianlin Han

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acute Respiratory Distress Syndrome
  • Biomedical Research
  • Blood
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Dysfunction
  • Endothelial Cells
  • Endotoxins
  • Epithelial Cells
  • Hemorrhagic Shock
  • Inflammation
  • Lipids
  • Lung Diseases
  • Maryland
  • Membrane Lipids
  • Metabolites
  • Metabolomics
  • Oxidative Stress
  • Standards
  • Stress (Physiology)
  • Thoracic Injuries
  • Tissues
  • United States
  • Vascular Endothelium
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology