Multimodal Remote Control of Gene Expression
Abstract
The objective of this research is to integrate both light-driven (optogenetic) and electronically-driven (electrogenetic) control of gene expression in bacterial cells for precise spatiotemporal control of multiple genes. Non-chemical modalities such as electronics and light offer more precise spatiotemporal control of genes than traditional chemical methods and can be used to remotely control cell function. There area number of optogenetic and electrogenetic systems that have been developed that work well in bacteria that were evaluated for a multimodal system. Precisely controlling when multiple genes in a pathway turn on and off can be a key technology in enabling optimal biosynthesis of materials and molecules of interest.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 10, 2021
- Accession Number
- AD1123128
Entities
People
- Tanya Tschirhart
Organizations
- United States Naval Research Laboratory