Characterizing Concussion Using Brain Derived Exosomes

Abstract

Traumatic brain injury (TBI) currently afflicts 357,000 enlisted military men and women in the US Armed Services. For the most common form of TBI, Mild Traumatic Brain Injury (mTBI) most patients recover within a year following the incident, but 10-20 of mild cases result in a long-term disability including seizures and emotional and behavioral issues. Although much has been learned about molecular changes in the brain following injury, access to these biomarkers following mTBI is lacking. The accurate diagnosis and precise individual clinical management of traumatic brain injury (TBI) is limited by the lack of accessible molecular biomarkers that are informative regarding the unique mixture of injury mechanisms in each TBI patient.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1123440

Entities

People

  • Danielle Sandsmark
  • Dave Meaney
  • David Issadore
  • Ramon Diaz-Arrastia

Organizations

  • University of Pennsylvania

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Astrocytes
  • Biomedical Research
  • Blood
  • Blood-Brain Barrier
  • Brain Injuries
  • Cells
  • Covid-19
  • Culture Techniques
  • Detection
  • Diseases And Disorders
  • Electronic Mail
  • Flow Rate
  • Infectious Diseases
  • Machine Learning
  • Magnetic Nanoparticles
  • Medical Personnel
  • Mobile Phones
  • Nanoparticles
  • Neurons
  • Particles
  • Recovery
  • Simulations
  • Students

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Oncology and Biomarker-Based Cancer Detection.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.