Pre-Clinical Assessment of Bioprinted Human Skin for Wound Healing and Skin Regeneration Research
Abstract
Burn injuries are major clinical and financial concerns for both the civilian and military populations. The current standard of care for permanent closure and wound coverage for full-thickness skin wounds is the use of skin autografts harvested from an uninjured donor site on the patient. However, in the case of extensive skin loss, the availability of donor sites for harvesting is limited. Tissue engineered skin substitutes are a promising alternative however, they have they do not stimulate full skin. In contrast, tissue bioprinting successfully closed large full-thickness wounds. A bioprinted full-thickness human skin construct, with stratified tri-layered structures containing epidermis, dermis and hypodermis skin will provide permanent wound closure in burn and trauma patients. It will lead to overall reduction in surgical procedures and hospital time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 17, 2021
- Accession Number
- AD1123453
Entities
People
- Shay Soker
Organizations
- Wake Forest University