Precision Combinatorial Immunotherapeutic Targeting of Cytokine Receptor Kinase Signaling in CRLF2-Rearranged ALL

Abstract

Ph-like ALL is a high-risk subset of B-ALL defined by an activated kinase gene expression profile similar to that of BCR-ABL1-rearranged (Ph+) ALL and driven by a diverse range of genetic alterations that activate cytokine receptor signaling pathways. Children, AYAs, and older adults with Ph-like ALL have >60% relapse risk and experience significant leukemia-associated mortality. Approximately 50% of Ph-like ALL cases harbor rearrangements in CRLF2 (CRLF2-R) and frequent concomitant JAK2 point mutations.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1123942

Entities

People

  • Sarah K. Tasian
  • Terry Fry

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  • Anschutz Medical Campus

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  • Abstracts
  • Antigens
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  • Cell Line
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  • Biotechnology - Cancer Biotech