Long-Term Followup of the Delayed Effects of Acute Radiation Exposure in Primates

Abstract

This program studies the mechanisms and consequences of delayed effects of acute radiation exposure (DEARE) in non-human primates (NHP), with complementary mechanistic and therapeutic studies in mice. The program consists of 4 projects, focused on: 1. Type 2 diabetes mellitus (T2DM); 2. Radiation-induced heart disease (RIHD); 3. Chronic immune impairment; and 4. Genomics and transcriptomics. Major findings include peripheral microvascular and bioenergetic abnormalities in NHP with T2DM; restrictive myocardial fibrosis in RIHD; dose and age-dependent immune impairment; and ongoing sequencing work which will inform us regarding the molecular pathogenesis of T2DM, RIHD, and immune impairment in the context of DEARE.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1124255

Entities

People

  • J M Cline

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Connective Tissue
  • Data Analysis
  • Diabetes Mellitus
  • Gene Expression
  • Genetics
  • Glucose Metabolism Disorders
  • Health Services
  • Heart Diseases
  • Lymphocytes
  • Medical Personnel
  • Metabolic Diseases
  • Stem Cells
  • Subcutaneous Tissue

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and Cellular Biology
  • Nuclear Civil Defense.
  • Toxicology/Environmental Toxicology