Role of the Leukotriene E4 Receptor GPR99 in Asthma
Abstract
We previously demonstrated that inhalation of common aeroallergens such as the house dust mite Dermatophagoides pteronyssinus and the mold Alternaria alternata elicits the generation of a potent proinflammatory lipid mediator, leukotriene E4 (LTE4), which is part of the cysteinyl leukotriene (CysLT) family. LTE4 promotes lung inflammation and release of mucus into the airway through its action on an epithelial G protein-coupled receptor called CysLT3R or GPR99 or OXGR1. During this period we have found that: 1) Epithelial brush cells (BrCs) are a dominant cell type making LTE4 in the airway in several important clinical settings. 2) Allergen-elicited BrC CysLT generation depends on a GPCR called P2Y2.3) GPR99 drives expansion of BrC number which is a key step in promoting BrC-dependent pulmonary inflammation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1124286
Entities
People
- Nora A Barrett
Organizations
- Brigham and Women's Hospital