Neurovascular Changes Associated with Olfactory Deficits in Early Parkinson's Disease

Abstract

The purpose of this study is to investigate neurovascular changes related to the olfactory deficits in early PD patients to develop novel biomarkers for PD. We plan to focus on these Specific Aims: 1) neurovascular abnormalities associated with olfactory deficits in early PD patients; 2) dynamic changes in neurovascular and metabolic parameters during olfactory stimuli in early PD patients; and 3) the progression of such neurovascular abnormalities across different stages of PD patients. During the third year, we have been focusing our efforts on patient recruitment and data acquisition and analysis. We recruited 17 patients and 3 controls in Year 3, slightly exceeding the stated recruitment target in the SOW. We continued to analyze the neuroimaging and clinical data acquired in PD patients. We published some of our initial results in the form of a peer reviewed journal article.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1124293

Entities

People

  • Jun Hua

Organizations

  • Kennedy Krieger Institute

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Acquisition
  • Alzheimer Disease
  • Arteries
  • Blood Vessels
  • Brain
  • Cardiovascular Physiological Processes
  • Data Acquisition
  • Data Analysis
  • Dementia
  • Diseases And Disorders
  • Health Services
  • Institutional Review Board
  • Magnetic Resonance
  • Medical Personnel
  • Movement Disorders
  • Neurodegeneration
  • Neuroimaging
  • Parkinson'S Disease
  • Psychology
  • Statistical Analysis
  • Tomography

Fields of Study

  • Biology
  • Medicine

Readers

  • Medical Imaging.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.