Precision Targeting of Castration Resistant Prostate Cancer with a Novel Ferrous Iron-Dependent Therapeutic Delivery and Tumor Imaging Strategy
Abstract
Background Iron is an essential nutrient in biology where, serving in cofactors of diverse enzymes, it enables one-electron oxidation and reduction processes. Access to iron is thus a key driver of proliferative disease and the oncogene MYC has been found to alter iron homeostasis so as to produce an augmented pool of intracellular Fe(II). We recently developed a new drug delivery approach inspired by the Fe(II)-dependent pharmacology of the antimalarial agents artemisinins and arterolane. Our preliminary in vitro and in vivo data suggest that prostate cancer is highly amenable to therapy and imaging using Fe(II)-sensitive reagents. Targeting soluble ferrous iron represents an entirely novel approach to image and treat prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1124322
Entities
People
- Michael J. Evans
Organizations
- University of California