Identification of Epigenetic Signatures as Biomarkers of Gulf War Illness

Abstract

The objective of this research proposal is to use integrated approaches to investigate epigenetics changes of GWI and correlate the epigenetic changes with GW-relevant exposures (PB, pesticides, sarin) to identify the biological indicators in GWI pathogenesis in a well-established cohort of Gulf War veterans from the large multi-site DOD-funded Boston Gulf War Illness Consortium (GWIC) (GW120037). The most significant accomplishments in the initial year was developing protocols and obtaining approval of human subject research plans so that samples could be received. A meeting with contributors from the University of Boston occurred to finalize experimental plans. Supplies and equipment were ordered to facilitate experimental plan.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1124968

Entities

People

  • Anthony P. Malanoski
  • Tomasz Leski

Organizations

  • United States Naval Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Biorepositories
  • Computational Biology
  • Consortiums
  • Contracts
  • Department Of Defense
  • Electronic Mail
  • Epigenetics
  • Flight Instruments
  • Ground Position Indicators
  • High Performance Computing
  • Identification
  • Information Operations
  • Instrumentation
  • Inventions
  • Maryland
  • Military Research
  • Navigational Equipment
  • Patent Applications
  • Persian Gulf Syndrome
  • Professional Development
  • Public Health
  • Universities

Readers

  • Clinical Trial Research.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.