A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

Abstract

Objective: Systemic low-grade inflammation is a prostate cancer risk factor in men of African descent, and correlates with West African ancestry, genetic susceptibility, a distinct tumor biology, and aggressive disease. Our overall objective is to understand these relationships with a view to informing prevention and therapeutic strategies. Impact: Our study will be the first to explore the relationship between systemic/chronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammationand tumor biology affects prostate cancer progression in a high-risk population, like African-American men, offers the opportunity to the develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.

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Document Details

Document Type
Technical Report
Publication Date
Oct 29, 2020
Accession Number
AD1124972

Entities

People

  • Stefan Ambs

Organizations

  • Geneva Foundation

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cardiovascular Diseases
  • Chemistry
  • Colon Cancer
  • Data Analysis
  • Data Science
  • Disease Attributes
  • Ethnic Groups
  • Genetics
  • Geography
  • Gut Microbiome
  • Health Services
  • Hepatitis
  • Human Behavior
  • Human Population
  • Liver Diseases
  • Medical Personnel
  • Microbiomes
  • Minority Groups
  • Native Americans
  • Neoplasms
  • Oncology

Fields of Study

  • Medicine

Readers

  • Oncology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech