Intravenously Infusible Nanoparticles to Stop Bleeding and Increase Survival Following Trauma
Abstract
Trauma induced bleeding is a major cause of fatality between ages 1 to 44, accounting for up to 50% of combat deaths. An immediate on-field intervention that can augment hemostasis can provide the scope of limiting uncontrollable bleeding and saving lives. While nanotherapeutics like hemostatic nanoparticles, that mimic the activity of fibrinogen, have shown promise in small animal models, translation to large animal models is often limited due to infusion reactions from systemic administration. We have worked on understanding and tuning the surface of the nanoparticles to overcome such a complement-mediated response. Over the last year, we have worked on a sensitive screening tool for complement activation due to nanoparticles and using that assay, we have pinned down the optimum stealth properties. The stealth hemostatic nanoparticles were deployed in an in vivo porcine trauma model to validate the safety and efficacy of the hemostatic nanoparticles.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1124974
Entities
People
- Erin Lavik
Organizations
- University of Maryland, Baltimore County