Therapeutic Function of Glucagon-Like Peptide-1 (GLP-1) for Hearing Restoration after Blast Exposure or Traumatic Brain Injury (TBI)
Abstract
The objective of this project is to determine the therapeutic function of Liraglutide (glucagon-like peptide-1 receptor (GLP-1R)) to mitigate the auditory injury after blast exposure in animal model of chinchilla. There are two aims: Aim 1. Identify the therapeutics of liraglutide in ameliorating auditory function injuries in both pre- and post-treatments in relation to the blast overpressure (BOP) level or traumatic brain injury (TBI) severity over different time courses. Aim 2. Investigate the beneficial effects of liraglutide on the mitigation of the central auditory damage following repetitive exposures to the low BOP or mild TBI. Accomplishments in Year 1 include: 1) therapeutic efficacy of liraglutide (drug) was tested in 4 experimental groups of chinchillas: pre- and post-blast drug treatment animals with both ears open or protected by hearing protection devices (e.g. earplugs) under BOP level of 3-5 psi for 6 blasts; 2) hearing function tests were conducted on Day 1 pre- and post-blast and on Days 4, 7, 14, or 28; 3) immunofluorescence imaging and analysis of chinchilla brain tissues from 4 drug-treated groups and two blast control groups (open and protected) were performed and compared. Results demonstrate that the effect of liraglutide on mitigation of hearing damage in ears with and without protection is different, and particularly the liraglutide affects hearing recovery process after blast exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1124999
Entities
People
- Rong Gan
Organizations
- University of Oklahoma