A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

Abstract

Objective: Systemic low-grade inflammation is a prostate cancer risk factor in men of African descent, and correlates with West African ancestry, genetic susceptibility, a distinct tumor biology, and aggressive disease. Our overall objective is to understand these relationships with a view to informing prevention and therapeutic strategies. Impact: Our study will be the first to explore the relationship between systemic/chronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammation and tumor biology affects prostate cancer progression in a high-risk population, like African-American men, offers the opportunity to the develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1125035

Entities

People

  • Clayton Yates

Organizations

  • Tuskegee University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • African Americans
  • Biomedical Research
  • Blood
  • Cells
  • Covid-19
  • Data Analysis
  • Data Science
  • Department Of Defense
  • Diseases And Disorders
  • Fatty Acids
  • Gene Expression
  • Inflammation
  • Medical Personnel
  • Minority Groups
  • Neoplasms
  • Oncology
  • Pilot Studies
  • Prostate
  • Prostate Cancer
  • Risk Factors
  • Rna Sequence Analysis
  • Students
  • Tissues
  • Vaccines

Fields of Study

  • Medicine

Readers

  • Oncology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology