Leveraging the Framingham Study to Investigate Relationships Between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
Abstract
A large body of evidence suggests that people experiencing a single or repetitive TBI in civilian and military settings may have an increased risk of late-life cognitive decline or neurodegenerative disease, including Alzheimers disease (AD) and AD-related dementias(ADRD). But the specific clinical features and neuropathological substrates of TBI-associated dementia, as well as the mechanisms underlying this apparent association, are less clear. This project leverages the extensive existing resources of the Framingham Heart Study (FHS),which includes access to a long-committed community-based study sample, as well as health, lifestyle, biomarker, genetic, cognitive, neuroimaging and neuropathological data. We are combining these existing resources with new self-report TBI and military service data. This study will comprehensively characterize the role of TBI and military service on key AD/ADRD outcomes, and identify genetic and non-genetic factors that modify these relationships.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1125037
Entities
People
- Jesse Mez