Autologous Stem Cell Transplant in the Treatment of Pulmonary Light Chain Deposition Disease
Abstract
Light chain deposition disease is a rare condition resulting in the deposition of light chains in organs and their subsequent dysfunction. It is often the consequence of unchecked light chain production by a plasma cell clone. Rarely does it manifest with solely pulmonary involvement, especially in the young, otherwise healthy patient. This article highlights the presentation and diagnosis of pulmonary light chain deposition disease in an active duty solider, the discovery of a plasma cell clone responsible for his symptomatology, and the therapy targeted at the plasma cell clone inducing pulmonary disease. This therapy included a novel, successful treatment with an autologous stem cell transplant. To date, it is amongst the first such documented successful bone marrow transplants in treatment of isolated pulmonary light chain deposition disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 2021
- Accession Number
- AD1125116
Entities
People
- Andrew Berglund
- Charles Volk
- Jeffrey R. Galvin
- Matthew Peterson
- Matthew Rendo
- Teri J. Franks
Organizations
- 59th Medical Wing
- Defense Health Agency
- Naval Medical Center San Diego
- San Antonio Military Medical Center
- University of Maryland School of Medicine