Study to Compare High Versus Low Volume Fluid Resuscitation Strategies in a Porcine Model (Sus scrofa) of Burn and Traumatic Brain Injury
Abstract
We developed a porcine model of combined burn and traumatic brain injury and compared different fluid resuscitation strategies. Methods: .Burns and traumatic brain injuries were created. Swine received either aggressive or restrictive fluid resuscitation. Following 8 hours of critical care, swine were euthanized. Tissue samples were collected, processed and reviewed by a blinded observer. Results: Pigs receiving aggressive resuscitation had significantly higher intraoperative weight gain, more urine output, longer time at goal mean arterial pressure, longer time at goal sodium concentration and lower blood urea nitrogen (BUN) concentrations compared with pigs receiving restrictive treatment. Relative to baseline, end of study hematocrit, BUN, aspartate transaminase, and potassium concentrations were significantly higher in both groups but not substantially different from each other. Grossly, there were no significant differences in brain lesions sizes between groups. Lung and liver pathology did not differ significantly between groups. The kidneys did. Histologic features in these tissues reflected congestion and edema. Discussion/Conclusion: Both groups appeared to be adequately resuscitated during the 8 hours of critical care. Elevated BUN and AST concentrations are commonly reported in burn patients and likely don't reflect kidney or liver pathology, as creatinine and liver-specific alanine aminotransferase concentrations were not elevated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 24, 2020
- Accession Number
- AD1125352
Entities
People
- Ian E Brown
Organizations
- David Grant USAF Medical Center