Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-Related Fatigue
Abstract
This proposal addresses the Biology and Measurement of MS symptoms focus area of FY18 MSRP Exploration Hypothesis Development Award. The overarching aim of this proposal is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers. [F-18]PBR06 and [C-11]MRB. The major developments in the progress of this project have been the following: 1. We received permission to resume recruitment of subjects on July 15, 2020. 2. We are pleased to report that we have recruited and obtained informed consent from 10 eligible subjects already (greater than 80 percent of the target sample size). 3 of these subjects have completed all the study related procedures (25 percent of the target sample size). Based on our preliminary data about the role of neuroinflammation in pathogenesis of MS-related fatigue, we had a manuscript published in the journal Neurology: Neuroimmunology and Neuroinflammation in September, 2020. The title of the manuscript is T Singhal, S Cicero, H Pan, K Carter, S Dubey, R Chu, B Glanz, S Hurwitz, S Tauhid, Mi-Ae Park, M Kijewski, E Stern, R Bakshi, D Silbersweig, and HL Weiner. Regional Microglial Activation in Substantia Nigra is linked with Fatigue in Multiple Sclerosis. (PMID 32769103)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1125448
Entities
People
- Tarun Singhal
Organizations
- Brigham and Women's Hospital