Measuring Glial Metabolism in Repetitive Brain Trauma and Alzheimer's Disease

Abstract

The overall aim of the study is to better understand glial metabolism within the context of repetitive brain impacts and Alzheimer's disease and its potential findings in veterans. In preparation for the start of the study, we have conducted a number of studies to quantify the improvement moving from 3T to 7T. We also present data comparing military and sports-related repetitive brain trauma and show that changes in glutamate show similar patterns. These results support our initial hypothesis and illustrate the importance of measuring glial metabolism using indirect detection of 13C-labeled metabolism.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2019
Accession Number
AD1125644

Entities

People

  • Alexander Lin
  • Robert Stern

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Alzheimer Disease
  • Biomedical Research
  • Brain Injuries
  • Chronic Encephalopathy
  • Craniocerebral Trauma
  • Data Acquisition
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Glutamates
  • Health Services
  • Hospitals
  • Magnetic Resonance
  • Maryland
  • Medical Personnel
  • Metabolic Pathways
  • Metabolism
  • Neurodegeneration
  • Procurement
  • Professional Development
  • Spectroscopy
  • Standards
  • Technology Transfer
  • Therapy
  • Urban Areas

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Theoretical Analysis.