Multi-Parametric Bioreactor for Functional Preservation of Vascularized Composite Allografts

Abstract

1. More than half of the combat-related injuries per peer reviewed analyses of the Joint Theater Trauma Registry sustained by Warfighters in Iraq and Afghanistan involved extremities or craniofacial structures. An estimated 40 percent of all combat casualties in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) resulted in injuries to the extremities, face, and head and neck structures. Vascularized composite allotransplantation has increasingly become a viable clinical treatment option for the treatment of complex craniofacial and limb defects. To date, more than 100 patients worldwide have benefited from VCA, the majority receiving hand or face transplants. However, the transformational potential of VCA is severely limited by short preservation times (4 - 6 hours). 2. This work will deliver ex vivo VCA perfusion technology intended to extend preservation time to 24 hours and minimize ischemia damage by efficient perfusion and multi-parametric monitoring.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1125832

Entities

People

  • Warren L Grayson

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abdomen
  • Afghanistan Conflict
  • Allografts
  • Biomedical Research
  • Bioreactors
  • Cells
  • Cold Storage
  • Combat Injuries
  • Composite Materials
  • Engineering
  • Engineers
  • Growth Factors
  • Iraqi-War
  • Medical Personnel
  • Monitoring
  • Professional Development
  • Transplants

Readers

  • Trauma Surgery or Emergency Medicine.
  • Trauma or Military Medicine

Technology Areas

  • Biotechnology