Tiered In Vitro Toxicity Testing of the Novel Energetic N-Propylnitroguanidine (PrNQ)

Abstract

The energetic and toxicological properties of N-propylnitroguanidine (PrNQ) are under assessment as a replacement for energetics in current use, such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and trinitrotoluene (TNT). This study evaluated the toxicity of PrNQ in several in vitro test systems, including the Ames mutagenicity assay, the Microtox Acute Toxicity Test System, and skin sensitization via the human cell line activation test (h-CLAT) and the direct peptide reactivity assay (DPRA). Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for further development of new munition compounds.

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Document Details

Document Type
Technical Report
Publication Date
Mar 12, 2021
Accession Number
AD1126238

Entities

People

  • Emily N. Reinke
  • Valerie H. Adams

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Anti-Bacterial Agents
  • Bacteria
  • Cell Line
  • Cells
  • Chemical Compounds
  • Cysteine
  • Data Analysis
  • Environment
  • Environmental Protection
  • Groundwater
  • Health
  • Lactic Acid
  • Liquid Chromatography
  • Medical Personnel
  • Mutagenicity Tests
  • Plastic Explosives
  • Public Health
  • Range Finding
  • Seizures
  • Sulfur Compounds
  • Test Methods
  • Toxicity

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology