Comparison of Peritoneal Dialysis Using a Bag Containing Potassium-Binding Beads to Conventional Peritoneal Dialysis in an Anephric Swine Model of Hyperkalemia (Sus scrofa)
Abstract
Objectives: The objective of this study was to compare an experimental method of peritoneal dialysis to a conventional method in an anephric model of hyperkalemia. The purpose of the experimental device was to achieve similar removal of serum potassium over a 6-hour critical care period using less peritoneal dialysate fluid. Methods: Six animals underwent bilateral nephrectomy and hyperkalemia was induced exogenously. Peritoneal dialysis catheters were placed. Subjects were randomized to conventional peritoneal dialysis (n=3) or the experimental treatment method (n=3) over a 6 hour time period. Samples were obtained from the peripheral bloodstream, the ingoing peritoneal dialysate (PD) fluid, and the outgoing PD fluid. Serum potassium, calcium, ionized calcium, lactate, were compared between groups over time. Results: Average dialysate fluid utilized in the experimental method was 3.33 L over the 6-hour period, while the conventional treatment used 12 L. There was no statistically significant difference in serum potassium between groups over time (p = 0.766) (Fig. 1). There were statistically significant differences between groups in serum calcium (p = 0.0008) but not ionized calcium (p = 0.5956) and lactate (p = 0.0004). Conclusion: In this model, the experimental device used significantly less fluid and was able to control serum potassium levels with similar efficacy to that of conventional peritoneal dialysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 18, 2020
- Accession Number
- AD1126287
Entities
People
- Ian J Stewart
Organizations
- David Grant USAF Medical Center