Ultrahigh Field MRI Detection of Biomarkers in Post Traumatic Epilepsy
Abstract
Post traumatic epilepsy (PTE) can be characterized as recurring seizures which develop after traumatic brain injury. There is often a significant delay between the manifestation of seizures and the initial injury. There is increasing evidence that suggests that epilepsy is a disease involving a network of abnormalities, and ultra-high field magnetic resonance imaging (MRI), such as systems operating at fields strengths of 7 Tesla (7T), enable exceptionally high-contrast, high-resolution in vivo imaging of the brain. If we can detect imaging biomarkers of changes specific to epileptogenesis following TBI we may be able to eventually develop treatments which target those mechanisms for antiepileptogenic therapy without compromising recovery from TBI or worsening the effects of other TBI co-morbidities. We are recruiting patients with TBI, PTE, and healthy controls as part of an imaging study. Patients with TBI are matched with the recruited PTE patients and healthy controls. Volunteer image data will be collected using an optimized TBI imaging protocol. The data will be processed to explore suspected biomarkers of epilepsy in all volunteers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2020
- Accession Number
- AD1126406
Entities
People
- Rebecca E Feldman
Organizations
- Mount Sinai Hospital