Diagnostic and Therapeutic Strategy to Prevent Trauma-Induced Upper-Extremity Muscle Fibrosis and Heterotopic Ossification

Abstract

Heterotopic ossification (HO), the formation of ectopic bone in soft tissue, and muscle fibrosis, severe scarring of muscle tissue, often result due to traumatic injury. The military population has been shown to be particularly as risk of these afflictions following battlefield trauma. Here, we investigate a class of hypoxia-targeting drugs as treatments for HO and traumatic muscle fibrosis. We also develop a high frequency spectral ultrasound imaging system (SUSI) to detect early HO lesions and muscle fibrosis in order to facilitate early treatment.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1126861

Entities

People

  • Benjamin Lévi

Organizations

  • Board of Regents of the University of Michigan

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Bone And Bones
  • Burns
  • Cells
  • Combat Injuries
  • Connective Tissue
  • Data Analysis
  • Frequency
  • Gene Expression
  • Health Services
  • Heterotopic Ossification
  • Leukocytes
  • Lower Extremity
  • Medical Personnel
  • Orthopedics
  • Osteogenesis
  • Peptide Growth Factors
  • Radio Frequency
  • Skeletal Muscle
  • Soft Tissues
  • Tendons
  • Therapy
  • Tissues
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Aerial Delivery - Logistics and Supply Chain Management.
  • Medical Imaging.
  • Trauma Surgery or Emergency Medicine.