Development of Exosomes-Based Theranostic for Lung Cancer

Abstract

This project was focused on development of novel theranostics for simultaneous treatment, measuring treatment response and diagnosis of lung cancer. Current chemotherapeutic interventions are though effective in inhibiting cancer cell growth under in vitro condition but loses their potency when administered to patients body. Absence of an efficient drug delivery system is the main cause of failure of chemotherapy. In addition, Lung cancer is often detected at late stages and current modalities of imaging are also not very precise. Hence the main objective of this project was to develop an efficient drug delivery vehicle, which can deliver drug precisely to the tumor site. In addition this vehicle also possessed ability to imaging using Magnetic Resonance Imagining (MRI) and is supposed to give precise imaging of tumor. The information generated in this project will serve as a proof of concept for the purposed technology and will open scope of future studies needed to develop it as a method that will enable clinicians to design precise and personalized treatment regimens.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1127501

Entities

People

  • Akhil Srivastava

Organizations

  • University of Oklahoma

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Chemotherapy
  • Covid-19
  • Culture Techniques
  • Department Of Defense
  • Drug Therapy
  • Electron Microscopy
  • Lung Cancer
  • Lymphocytes
  • Magnetic Resonance
  • Mass Spectrometry
  • Medical Personnel
  • Nanoparticles
  • Neoplasms
  • Oklahoma
  • Personalized Medicine
  • Theranostics
  • Therapy
  • Universities

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Oncology