Contribution of the ArsRS Two-Component System and HomB to Helicobacter pylori Biofilm Formation

Abstract

Discovery of H. pylori within the human stomach not only defied the dogma that the human stomach was a sterile environment, but also revolutionized the treatment of gastric and duodenal ulcers. Moreover, H. pylori became the first, and only, bacterium to be classified as a class I carcinogen. While, treatment of H. pylori infection leads to beneficial outcomes with respect to incidence of peptic ulcer disease and gastric cancers, treatment failure following H. pylori eradication therapy can be as high as 20 ; rates of resistance continue to rise. For a pathogen in which a two-week course of triple or quadruple therapy is already the current recommendation, the need for a better treatment regimen is evident.

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Document Details

Document Type
Technical Report
Publication Date
Dec 08, 2016
Accession Number
AD1127813

Entities

People

  • Stephanie L. Servetas

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Bacteria
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Culture Media
  • Drinking Water
  • Eukaryotes
  • Genetic Variation
  • Genetics
  • Gram-Negative Bacteria
  • Intestinal Diseases
  • Microbiology
  • Microorganisms
  • Pathogenic Bacteria
  • Proteins

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Technology Areas

  • Biotechnology