Concentration of Epinephrine and Anesthetic in Local Anesthetics Exposed to Environmental Extremes
Abstract
The purpose of this study was to evaluate the concentrations of epinephrine and anesthetic in dental anesthetic carpules after storage in simulated deployed environments. Two test environments, the first simulating the hot environment of Djibouti, Djibouti and the second simulating the cold environment of Bishkek, Kyrgyzstan, were used to store carpules of Articaine 4 with 1:100,000 epinephrine and Lidocaine 2 with 1:100,000 epinephrine. The Djibouti environment cycled between 41C/39 humidity and 31C/50 humidity. The Bishkek environment cycled between -4C and -8C. Control groups were stored at 22.2C and 50 humidity. Epinephrine and anesthetic concentrations in Articaine and Lidocaine local anesthetics were analyzed using highperformance liquid chromatography (HPLC) at baseline, 1 week, 2 weeks, and 1 month of storage. The levels of anesthetic and epinephrine were statistically analyzed per anesthetic type and temperature with Dunnetts tests comparing each week of storage to baseline (alpha=0.05). No significant difference in the levels of anesthetic or epinephrine was found based on storage temperature or time for either type of anesthetic (p>0.05). Storage of cartridges of anesthetic over time at hot or cold temperatures does not significantly affect the levels of anesthetic or epinephrine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 28, 2014
- Accession Number
- AD1127832
Entities
People
- Paula Morse
Organizations
- Uniformed Services University of the Health Sciences