Observations and Identification of a Novel Population of Parietal Ridge Osteoprogenitor Stem Cells in a Rat Critical-Sized Calvarial Defect Bone Regeneration Model
Abstract
It has been previously observed that, after creation of a critical-sized calvarial defect, a rat model exhibits bone healing initiation from two distinct foci: the underlying dura mater and the adjacent parietal ridge bone eminence. During healing, distinct islands of cartilage appear in the dural region but do not appear near the parietal ridge. This study utilized immunohistochemistry to investigate how stem/osteoprogenitor cells in the parietal ridge region differed in their healing response in the presence of varying concentrations of recombinant human bone morphogenetic protein-2. Response to the markers used was observed to be different in the two regions of interest. These data support that the stem/osteoprogenitor cells within these two regions represent distinct subtypes not previously identified.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 04, 2019
- Accession Number
- AD1127895
Entities
People
- Richard B. Hill
Organizations
- Uniformed Services University of the Health Sciences