Periodontal Regeneration of 1-and 2-Wall Intrabony Defects Using Bioxclude with Freeze-Dried Bone Allograft
Abstract
When oral hygiene and non-surgical therapies cannot control periodontitis, surgical therapy is advised to clean deep pockets and try to create periodontal architecture for efficient plaque control to minimize recurrence of disease. In order to restore health to the periodontium, regenerative therapy, aimed at re-growing lost periodontal structures, is often employed to improve post-surgical architecture and improve probing depths (PD) and clinical attachment levels (CAL). Purpose: The objective of this case series was to determine if BioXclude , an amnion-chorion allograft membrane shown to contain over 55 growth factors, provided predictable periodontal regeneration (formation of new bone, cementum, and connective tissue around teeth) when used in conjunction with freeze-dried bone allograft (FDBA) for the treatment of 1- and 2-wall intrabony defects. Methods: Subjects undergoing treatment of 1- and 2- wall intrabony defects were assigned to receive guided tissue regeneration with bone graft utilizing FDBA and BioXclude membrane. Customized plastic stents were used by blinded investigators to obtain standardized measurements reflecting changes in PD, CAL and recession (REC).Bleeding on probing and plaque were classified as present or absent. PD, CAL and REC were assessed at the deepest defect sites at baseline (time of surgical treatment) and 6-months after surgical treatment. During surgery, the depth, mesiodistal width and buccolingual dimension of the intrabony defect were measured after the defect was debrided and the defect was classified as either 1-, 2-wall or a combination defect. The postoperative healing of each patient was assessed at weeks 1, 2, 4, 6, 8 weeks and again at 3 and 6 months. Data analysis compared changes in PD, CAL and REC. The improvement in each of these dependent measures was assessed using the paired Wilcoxon signed-rank test. Results: Seven subjects with eight 1-, 2-wall or combination intrabony defects were evaluated. From baseline
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2018
- Accession Number
- AD1128266
Entities
People
- Amanda A. Fix
Organizations
- Uniformed Services University of the Health Sciences