Racial Differences in Systemic and Prostatic Inflammation
Abstract
Black men have a 67% higher prostate cancer (PC) risk than white men and over twice the mortality. While in general, black men have reduced access to care, within an equal access setting, we found they had higher grade disease at diagnosis and higher risk of cancer recurrence after surgery. These findings suggest underlying biological differences between black and white men. Recent data suggest differences in how the immune system and tumor interact may contribute to the more aggressive disease among black men. However, there are surprisingly limited data on inflammation and PC risk in black men despite compelling data suggesting inflammation varies by race. Nearly all the data linking inflammation and PC risk was derived from studies of largely white men. Our study will fill two major voids in the literature: 1) how inflammation links with PC and 2) how race links with inflammation. We will characterize and test which systemic and prostatic inflammatory markers are linked with PC risk and aggressiveness in black and white men, leading to the development of inflammatory-based biomarker panels to detect those most likely to have aggressive disease aiding risk stratification of whom to biopsy and treat; key PCRP focus areas.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2021
- Accession Number
- AD1128321
Entities
People
- Adriana C. Vidal
- Stephen J. Freedland
Organizations
- Cedars-Sinai Medical Center