Bone Regeneration Device for Compromised Wounds
Abstract
This device will promote bone regeneration in compromised wounds. It addresses the critical limiting factors in repair: low osteo/chondro-progenitors, low vascular supply, and a fibrotic immune response. Our hypothesis that controlled prolonged delivery of the immunomodulatory and chondrogenic cytokines will promote bone regeneration in both comminuted fractures and critically sized bone void defects compared to no cytokine delivery. We also hypothesize that the hydrogel component will promote bone regeneration in both models via formation of a larger cartilaginous callus-like tissue. The device is designed to be applied via two different modalities depending on the nature of the bone injury: an Injectable Hydrogel device and an Implantable Hydrogel Infused Scaffold device. The injectable hydrogel is used to treat comminuted fractures and small bone deficits while the implantable hydrogel infused scaffold is used to treat large bone deficits. We will test the injectable device in a bi-lateral simulated comminuted fractures of the fibulas while the implantable device in bi-lateral fibular segmental defects in swine. The Specific Aims are: 1. Manufacture the bone regeneration devices; 2. Assess the immunomodulatory effect and potential for endochondral ossification at 1 month post-surgery; 3. Assess the functional bone healing response after 5 months post-surgery(bone formation and strength, revascularization and reinnervation).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1128345
Entities
People
- Alejandro Almarza
- Erik Weitzel
- Juan M Taboas
Organizations
- University of Pittsburgh