Identification of Glycomic Alterations During Melanoma Metastasis
Abstract
We hypothesized that the ability of melanoma cells to abandon the primary site, survive, and grow in distal organs requires changes in glycosylation, some of which are site-specific. Our primary objective is to identify glycomic changes in melanoma that: 1) predict the ability of primary melanoma to metastasize and 2) promote colonization of distal organs, and particularly the brain. In the first year of funding we have obtained a large cohort of primary and metastatic melanomas (to different sites of metastasis) which we will examine for glycan profiling (Aim 1). This analysis is expected to reveal glycan signatures associated with metastasis in general, or to organ-specific tropism. On the other hand, we have conducted in vivo experiments that have provided further evidence of the ability of FUT8 inhibition to interfere with the growth of already established metastasis (Aim2). These findings support the development of FUT8 inhibitors as new therapeutic agents for melanoma treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2020
- Accession Number
- AD1128362
Entities
People
- Eva Hernando-monge
Organizations
- Grossman School of Medicine