The Molecular Mechanism of PRDM9 During Meiosis in the Mouse

Abstract

Meiotic homologous recombination is vital for accurate segregation of the homologous chromosomes in the first meiotic division, and infertility, miscarriage and developmental disabilities can result when this process is impaired. Additionally, meiotic homologous recombination generates genetic diversity. During meiosis, recombination predominantly occurs at recombination hotspots determined by the DNA-binding protein PRDM9, which is essential for fertility. PRDM9 marks where homologous recombination can occur with a histone modification, H3K4me3.

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Document Details

Document Type
Technical Report
Publication Date
Oct 11, 2017
Accession Number
AD1128404

Entities

People

  • Sarah Thibault-sennett

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Biology
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Chromosomes
  • Embryos
  • Gene Expression
  • Genetics
  • Genomics
  • Germ Cells
  • Proteins
  • Sex Glands
  • Spermatozoa
  • Stem Cells
  • Testes

Fields of Study

  • Biology

Readers

  • Allergy and Immunology.
  • Molecular Biology and Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology