The Impact of Age on Microglial Activation, Glucose Uptake, and Functional Recovery from Spinal Cord Injury

Abstract

The number of spinal cord injury (SCI) cases among people middle-aged or older has been steadily increasing over the past 4 decades, and currently, the average of age of onset of SCI is 42. Increasing age at time of injury is correlated with worsened functional outcome and injury severity, and is associated with higher rates of co-morbidities and mortalities. DNA mutations are found in tissue by middle-age, leading to changes in cellular response genes. These include increased inflammatory genes which lead to increased oxidative damage and chronic inflammation. Aged microglia (the primary immune and inflammatory responder in the central nervous system (CNS) show basally increased pro-inflammatory activity, considered a primed state of activation, which is hyper-responsive, causing a more deleterious effect on injury severity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 12, 2017
Accession Number
AD1128421

Entities

People

  • Ramona E. Von Leden

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Blood
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Central Nervous System
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Epithelial Cells
  • Free Radicals
  • Health Services
  • Metabolism
  • Nervous System
  • Neurodegeneration
  • Neuroglia
  • Neurosciences
  • Oxidative Stress
  • Parkinson'S Disease
  • Proteins
  • Spinal Column
  • Spinal Cord
  • Spinal Injuries
  • Spine
  • Therapy
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Mathematics or Statistics
  • Neurotrauma and Rehabilitation Medicine.
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