Roles of Lymphatic Vessels in Cardiac Tissue Regeneration
Abstract
Heart failure is the leading cause of death in the US and globally. There is a pressing need for novel therapeutic interventions to prevent heart failure in patients with coronary heart diseases. Tissue regeneration holds great promise of treating organ injures and chronic diseases, including coronary heart disease. We proposed to investigate the roles of cardiac lymphatic vessels in revascularization and immune modulation, two processes important for heart regeneration. Our preliminary data suggest that cardiac lymphatic vessels can carry blood and perfuse myocardium of zebrafish, an animal with remarkable capacity of heart regeneration. These cardiac lymphatic vessels form in close association with coronary arteries, conserved with human hearts. We also found that hearts with impaired cardiac lymphatic vessels fail to regenerate. We will continue to investigate how cardiac lymphatic vessels modulate revascularization and immune cell clearance. Molecular mechanisms underlying cardiac lymphatic vessel formation after heart injury might lead to development of novel therapeutic design of myocardial revascularization and regeneration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2021
- Accession Number
- AD1128668
Entities
People
- Ching-ling Lien
Organizations
- Children's Hospital Los Angeles