Genomic and Biological Risk Prediction of Aggressive and Lethal Prostate Cancer in African-American Men
Abstract
Despite robust and consistent evidence showing African-American men have poorer prostate cancerx2;specific outcomes, risk stratification tools (based on prostate-specific antigen, Gleason score, and tumor stage) are not currently able to incorporate racial disparities in a clinically meaningful way and identifying which men are at an increased risk of lethal prostate cancer remains a major challenge to the field. To this end, the purpose of this project is to develop a novel genomic/biological risk prediction approach to prostate cancer in men of African descent by identifying and developing a genomic signature/risk-classifier that is predictive of aggressive and potentially lethal prostate cancer. The resulting genomic/biological signature could identify African-descent men most likely to be at risk of lethal prostate cancer. We proposed to do this by: Aim 1: Identify and validate scenarios where current prostate cancer risk assessment tools are least prognostic in African-American men. Aim 2: Identify and characterize the prostate cancer genomic risk profile in African-descent men compared with European-descent men, particularly in clinical scenarios identified in Aim 1. Aim 3: Incorporate the findings from AIMs 1 and 2 into the development of a genomic-risk classifier/biomarker signature that is targeted toward the prediction of aggressive and potentially lethal prostate cancer in men of African descent and to determine whether the signature adds prognostic value to current clinical nomograms. Preliminary work from this grant has demonstrated that there are genomic differences observed by race, particularly in metastatic disease: in a study of over 2k patients, Black men were most likely to have AR alterations, DDR alterations, and alterations in targetable genes (Mahal, NEJM 2020.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2020
- Accession Number
- AD1129000
Entities
People
- Brandon A Mahal
Organizations
- University of Miami