Development of a Splice-Switching Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy

Abstract

Determine how long SMN protein levels are elevated in E1v1.11 treated mice analyzed via SMN ELISA assay. These samples were collected in early 2020 and analyzed via ELISA by a vendor. Due to processing complications, some of these samples need to be verified, which was to be initiated in March 2020 but halted due to the campus-wide shutdown because of Covid-19. This shutdown slowed and nearly stopped research capabilities for several months. These studies are now ongoing following university policies in regards to Covid-safe access protocols.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1129280

Entities

People

  • Christian Lorson

Tags

DTIC Thesaurus Topics

  • Antisense Elements (Genetics)
  • Biomedical Research
  • Blood
  • Blood Cells
  • Blood Chemistry
  • Body Weight
  • Cell Count
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Covid-19
  • Data Analysis
  • Education
  • Electronic Mail
  • Granulocytes
  • Leukocytes
  • Materials
  • Medical Personnel
  • Proteins
  • Sars
  • Spinal Cord
  • Therapy
  • Universities

Readers

  • Industrial Economics
  • Molecular Genetics
  • Neurotrauma and Rehabilitation Medicine.