Early Critical Care Decisions and Outcomes after SCI: Track-SCI

Abstract

This project was a continuation of a prospective observational study of early critical care practices and predictors of outcome in acute spinal cord injury (SCI) conducted at the UCSF campus at the Zuckerberg San Francisco General Hospital and Trauma Center and at the UCSF Fresno Medical Center. The project continues on as an expansion of this award (SC150198) which was funded beginning 08/14/2020 (SC190233). Using NINDS SCI common data elements (CDEs) and a custom REDCap database we collected detailed physiological, imaging, and treatment data on every enrollable SCI admission to these two level 1 trauma centers. Our objective was to provide a comprehensive prospective analysis of multiple variables in acute SCI that impact longterm outcomes. Most participants received follow-up interviews and ISNCSCI /ASIA neurological scores and classification at 6 and 12 months. Critical care variables included surgical timing and procedure, ICU management and physiological monitoring of blood pressure, pharmacological treatments, and all variables listed in the NINDS CDEs, with special attention to cardiovascular and autonomic variables. High resolution MR imaging was paired witha tool kit of post- processing procedures that will be combined with physiological, genomic, and treatment variables to produce predictive prognostic models in the future. Guidelines based on best practices identified during the study will be communicated to both the military and civilian SCI patient care communities. White blood cells (WBC) were isolated from blood samples from acute SCI patients were used to provide WBC gene expression profiles via messenger RNA deep sequencing (RNAseq). These profiles were used to begin identification of diagnostic and prognostic biomarkers for acute SCI.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2020
Accession Number
AD1130723

Entities

People

  • Jacqueline Bresnahan
  • Michael S Beattie
  • Xuan Duong-fernandez

Organizations

  • University of California Regents

Tags

Communities of Interest

  • Autonomy
  • Human Systems

DTIC Thesaurus Topics

  • Big Data
  • Blood Cells
  • Cardiovascular Physiological Phenomena
  • Central Nervous System
  • Computational Science
  • Data Analysis
  • Data Curation
  • Data Mining
  • Data Sets
  • Databases
  • Gene Expression
  • Health Services
  • Information Science
  • Leukocytes
  • Machine Learning
  • Magnetic Resonance
  • Medical Personnel
  • Neural Networks
  • Patient Care
  • Physiological Monitoring
  • Social Media
  • Spinal Cord
  • Spinal Injuries
  • Standards
  • Therapy

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Oncology and Biomarker-Based Cancer Detection.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.